Sandbox Reserved 962

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This Sandbox is Reserved from 15/11/2014, through 15/05/2015 for use in the course "Biomolecule" taught by Bruno Kieffer at the Strasbourg University. This reservation includes Sandbox Reserved 951 through Sandbox Reserved 975.

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mRNA Cap (Guanine-N7) Methyltransferase (Ecm1)

spinqualitylabelsall models Ecm1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 Function 2 Structure 3 Interaction 3.1 Interaction with a Cap Analogue (7-methylguanosine-5-triphosphate-5-Guanosine) 3.2 Interaction with AdoHcy (S-adenosyl-L-homocysteine) 4 Post transcriptional modifications 5 References

Function

Structure

Interaction

Interaction with a Cap Analogue (7-methylguanosine-5-triphosphate-5-Guanosine)

Interaction with AdoHcy (S-adenosyl-L-homocysteine)

The mRNA Cap Methyltransferase bind to which is the product of the methyl donor AdoMet after the methylation. Adohcys is in a pocket formed by amino acids of segment 2. (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. The interactions between AdoHcys and the enzyme are made of : hydrogen bonds, Van der Walls interactions,electrostatic interaction and water mediated contact.

Post transcriptional modifications

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References