Structural highlights
Publication Abstract from PubMed
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.
Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG. Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786 doi:http://dx.doi.org/10.1126/science.1261962
