Acetyl-CoA synthetase

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Template:STRUCTURE 2p2j

Acetyl-CoA synthetase (ACS) catalyzes the ligation of acetate and CoA to form acetyl-CoA with the conversion of ATP to AMP and pyrophosphate. ACS is an ATP-dependent AMP-binding enzyme. Mg+2 is ACS cofactor.

Function

ACS participates in the pathway which fixes CO2 under anaerobic conditions. ACS acetylates the response regulator for flagellar movement and for chemotaxis - CheY.

Relevance

Acetyl-CoA is used in aerobic respiration to produce energy and electron carriers and for lipid biosynthesis, in histone acetylation which is critical for DNA condensation to chromatin.

3D structures of acetyl-CoA synthetase

Updated on 22-October-2015


1pg3, 1pg4 – SeACS (mutant) + CoA + AMP – Salmonella enterica
2p20, 2p2m, 2p2q - StACS (mutant) + AMP – Salmonella typhimurium
2p2b, 2p2j - StACS (mutant) + CoA + AMP
2p2f - StACS + CoA + AMP
1ry2 – ACS + AMP - yeast
4u5y – ACS GNAT domain + SeACS C terminal (mutant) – Streptomyces lividans

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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