1ldp
From Proteopedia
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CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES
Overview
MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity, alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a, mixture of bound peptides at 3.1 A to construct a model of the allogeneic, 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure., A prominent ridge on the floor of the Ld peptide-binding groove, not, present in Kb, creates a C-terminal bulge in Ld peptides that greatly, increases interactions with the 2C beta-chain. Furthermore, weak, electrostatic complementarity between Asp77 on the alpha1 helix of Kb and, 2C is enhanced in the allogeneic complex by closer proximity of QL9, peptide residue AspP8 to the 2C HV4 loop.
About this Structure
1LDP is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus with NDG as ligand. Structure known Active Sites: CNP and CNQ. Full crystallographic information is available from OCA.
Reference
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:9620676
Page seeded by OCA on Mon Nov 5 16:42:22 2007
