Sandbox Reserved 434

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Estrogen receptor beta/genistein complex 2 Introduction 3 Overall Structure 4 Binding Interactions 5 Additional Features 6 Quiz Question 1 7 Quiz Question 2 8 See Also 9 Credits 10 References

Estrogen receptor beta/genistein complex

Introduction

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This is a sample scene created with SAT to by Group, and another to make of the protein.

The estrogen receptor beta is one of the two isoforms of the estrogen receptor, a ligand-activated transcription factor, which regulates the biological effects of the steroid hormone 17 beta-estradiol, or estrogen, in both males and females.

Overall Structure

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Estrogen receptor beta and genistein complex consists of 4 chains. The phytoestrogen, genistein, is completely buried in the hydrophobic core of the protein. Its bicyclic form allows the ligand to hydrogen bond on opposite sides with the hydroxyls of the histidine groups on the receptor. (His475)

Estrogen receptor beta contains several domains for different functions. Its N-terminal domain (NTD) consists most of random coils and a small portion of helices and sheets. This lack of structure allows it to recruit and bond proper interaction partners. Within the NTD, the A and B domains can transactivate transcription without binding estrogen, and the C domain or the DNA binding domain (DBD) that binds estrogen response elements of DNA. The D domain is a hinge region connecting DBD to the E domain, ligand binding domain (LBD), at the C terminal.

Binding Interactions

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Additional Features

Quiz Question 1

Quiz Question 2

See Also

• UvrABC
• Androgen receptor
• Estrogen receptor
• Estrogen-related receptor
• Nuclear receptor coactivator
• Hormone
• Glycogen synthase kinase 3
• CREB-binding protein

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - name of team member

Quiz Question 2 - name of team member

References