Dynactin

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Image:2hkq.png
Crystal Structure of Dynactin (green) complex with protein linker (grey), 2hkq

Template:STRUCTURE 2hl5

















Dynactin (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.[1]









3D Structures of Dynactin

Updated on 11-January-2016

2coy - hDCTN subunit 1 CAP-Gly domain – human – NMR
3e2u – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1
2hkq, 2hl3, 1txq - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal
2hqh - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain
2hl5, 3tq7 - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
2m02 - DCTN subunit 1 CAP-Gly domain – rat – NMR
3tv0 - hDCTN subunit 6
5aft – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM
5afu – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM

References

  1. ↑ Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec;115(6):1639-50. PMID:1836789

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Michal Harel, Alexander Berchansky

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