Formyl-CoA transferase

Formyl-CoA transferase (FCT) catalyzes the conversion of formyl-CoA and oxalate to formate and oxalyl-CoA. FCT takes part in the oxalate degradation pathway^[1].

Function

Disease

Relevance

Structural highlights

3D structures of formyl-CoA transferase

Updated on 23-January-2016

1p5h – OfFCT – Oxalobacter formigenes

1t3z, 2vjn, 2vjp, 2vjq – OfFCT (mutant)
1p5r, 2vjk, 2vjl – OfFCT + CoA
1vgq, 1vgr – OfFCT (mutant) + CoA
1t4c – OfFCT + oxalyl-aspartyl anhydride + CoA
2vjm – OfFCT + aspartyl-formyl anhydride + CoA
2vjo – OfFCT (mutant) + oxalate + CoA

References

1. ↑ Ricagno S, Jonsson S, Richards N, Lindqvist Y. Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. EMBO J. 2003 Jul 1;22(13):3210-9. PMID:12839984 doi:http://dx.doi.org/10.1093/emboj/cdg333