Plasmepsin

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Contents 1 Function 2 Relevance 3 3D structures of plasmepsin 4 References

Function

Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP).

• Proplasmepsin II exhibits a large shift between its domains which renders the protease inactive.

Relevance

Plm is a potential target for anti-malaria drugs^[1].

3D structures of plasmepsin

Updated on 04-July-2016

References

1. ↑ Huizing AP, Mondal M, Hirsch AK. Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors. J Med Chem. 2015 Jul 9;58(13):5151-63. doi: 10.1021/jm5014133. Epub 2015 Mar 17. PMID:25719272 doi:http://dx.doi.org/10.1021/jm5014133