Plasminogen

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Contents 1 Function 2 Disease 3 3D Structures of plasminogen 4 References

Function

Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors.

Disease

PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces^[1].

3D Structures of plasminogen

Updated on 04-July-2016

References

1. ↑ Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID:19141167 doi:http://dx.doi.org/10.1111/j.1365-2516.2008.01825.x