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2z6h
From Proteopedia
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| , resolution 2.20Å | |||||||
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| Domains: | ARM, ARM | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain
Overview
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
About this Structure
2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222
Page seeded by OCA on Wed Mar 26 10:03:19 2008
Categories: Homo sapiens | Single protein | Liu, J. | Moon, R. | Takemaru, K. | Xing, Y. | Xu, W. | Zheng, J. | Activator | Alternative splicing | Beta-catenin | C-terminal domain | Cell adhesion | Crystal structure | Cytoplasm | Cytoskeleton | Disease mutation | Nucleus | Phosphorylation | Polymorphism | Structural protein | Transcription | Transcription regulation | Ubl conjugation | Wnt signaling pathway
