4zr0

Structural highlights

Function

[SCS7_YEAST] Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Swain E, Baudry K, Stukey J, McDonough V, Germann M, Nickels JT Jr. Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. J Biol Chem. 2002 Jul 19;277(29):26177-84. Epub 2002 May 10. PMID:12006573 doi:http://dx.doi.org/10.1074/jbc.M204115200
2. ↑ Guan XL, Wenk MR. Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Yeast. 2006 Apr 30;23(6):465-77. PMID:16652392 doi:http://dx.doi.org/10.1002/yea.1362
3. ↑ Bosson R, Guillas I, Vionnet C, Roubaty C, Conzelmann A. Incorporation of ceramides into Saccharomyces cerevisiae glycosylphosphatidylinositol-anchored proteins can be monitored in vitro. Eukaryot Cell. 2009 Mar;8(3):306-14. doi: 10.1128/EC.00257-08. Epub 2008 Dec 12. PMID:19074599 doi:http://dx.doi.org/10.1128/EC.00257-08
4. ↑ Mitchell AG, Martin CE. Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. J Biol Chem. 1997 Nov 7;272(45):28281-8. PMID:9353282
5. ↑ Haak D, Gable K, Beeler T, Dunn T. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J Biol Chem. 1997 Nov 21;272(47):29704-10. PMID:9368039
6. ↑ Dunn TM, Haak D, Monaghan E, Beeler TJ. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Yeast. 1998 Mar 15;14(4):311-21. PMID:9559540 doi:<311::AID-YEA220>3.0.CO;2-B http://dx.doi.org/10.1002/(SICI)1097-0061(19980315)14:4<311::AID-YEA220>3.0.CO;2-B