4nc6

Structural highlights

Function

[RBGP1_HUMAN] May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.^{[1] [2]}

References

1. ↑ Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 1999 Apr 1;18(7):1772-82. PMID:10202141 doi:http://dx.doi.org/10.1093/emboj/18.7.1772
2. ↑ Miserey-Lenkei S, Couedel-Courteille A, Del Nery E, Bardin S, Piel M, Racine V, Sibarita JB, Perez F, Bornens M, Goud B. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J. 2006 Jan 25;25(2):278-89. Epub 2006 Jan 5. PMID:16395330 doi:http://dx.doi.org/7600929