2f9b
From Proteopedia
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| , resolution 2.54Å | |||||||
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| Ligands: | |||||||
| Gene: | F7 (Homo sapiens), F3 (Homo sapiens) | ||||||
| Activity: | Coagulation factor VIIa, with EC number 3.4.21.21 | ||||||
| Related: | 1O5D
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Discovery of Novel Heterocyclic Factor VIIa Inhibitors
Contents |
Overview
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
Disease
Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
2F9B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of novel heterocyclic factor VIIa inhibitors., Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB, Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. Epub 2006 Feb 3. PMID:16460932
Page seeded by OCA on Mon Mar 31 02:59:45 2008
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Cabuslay, R. | Hendrix, J. | Katz, B A. | Kolesnikov, A. | Rai, R. | Sanford, E. | Shrader, W D. | Sprengeler, P A. | Stephens, R. | Ton, T. | Torkelson, S. | Young, W B. | Yu, C. | Active site-directed inhibitor | Serine protease | Short hydrogen bond
