Cyclin-dependent kinase regulatory subunit

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models Human CKS 1 complex with phosphate (PDB code 1dks) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left. CKS1 is essential for CDK5 functioning in neuronal diferentiation. CKS exists as hexamer of homodimers and can bind six kinase molecules. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights

3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 12-October-2015 {{#tree:id=OrganizedByTopic|openlevels=0|

• CKS

• • 4lpa, 1qb3 – yCKS 1 - yeast
    
  • 3qy2 – yCKS 1 (mutant)
    
  • 1puc, 1sce – fyCKS 1 – fission yeast
    
  • 1dks, 1dkt – hCKS 1 - human
    
  • 1cks – hCKS 2
    

• CKS complexes

• • 4yc6 – hCKS 1 + CDK1
    
  • 1buh – hCKS 1 + CDK2
    
  • 1h4l, 1ung – hCKS 1 + CDK5
    
  • 1unh, 1unl – hCKS 1 + CDK5 + inhibitor
    
  • 3o0g – hCKS 1 + CDK5 + ATP analog
    
  • 2ass – hCKS 1 + Skp1 + Skp2
    
  • 2ast – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide
    
  • 4y72 – hCKS 2 + cyclin B1 + CDK1
    

}

References