Arylamine N-acetyltransferase

Function

Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine.

Relevance

Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.

Structural highlights

3D structures of arylamine N-acetyltransferase

Updated on 05-November-2015