Structural highlights
Function
[KHDR3_HUMAN] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.[1] [2] [3]
References
- ↑ Lee J, Burr JG. Salpalpha and Salpbeta, growth-arresting homologs of Sam68. Gene. 1999 Nov 15;240(1):133-47. PMID:10564820
- ↑ Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K, Wong-Staal F. A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. J Biol Chem. 2002 Feb 22;277(8):5778-84. Epub 2001 Dec 7. PMID:11741900 doi:http://dx.doi.org/10.1074/jbc.M106836200
- ↑ Cohen CD, Doran PP, Blattner SM, Merkle M, Wang GQ, Schmid H, Mathieson PW, Saleem MA, Henger A, Rastaldi MP, Kretzler M. Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor. J Am Soc Nephrol. 2005 Jul;16(7):1958-65. Epub 2005 May 18. PMID:15901763 doi:http://dx.doi.org/10.1681/ASN.2005020204
