Atlastin

From Proteopedia

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spinqualitylabelsall models Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code 4ido). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Atlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.[1] Disease Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Structural highlights from human atlastin (PDB code 4ido).[1]

3D structures of atlastin

Updated on 12-March-2017

3q5d, 3q5e, 3qnu, 3qof – hATN cytoplasmic domain + GDP – human
4idn – hATN cytoplasmic domain + GNP
4idp – hATN cytoplasmic domain (mutant) + GNP
4ido – hATN cytoplasmic domain + GDP + AlF4
4idq – hATN cytoplasmic domain (mutant) + GDP + AlF4
3x1d – ATN + GDP – Drosophila melanogaster

References

1. ↑ ^{1.0 1.1} Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353