Structural highlights
Function
[TIPRL_HUMAN] May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.[1]
References
- ↑ McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene. 2007 Sep 6;26(41):6021-30. Epub 2007 Mar 26. PMID:17384681 doi:http://dx.doi.org/10.1038/sj.onc.1210406
