Function
D-xylose isomerase (DXI) catalyzes the conversion of D-xylose (DX) to D-xylitol. DXI is part of the fructose and mannose metabolism pathways. Sorbitol is a competitive inhibitor of DXI. DXI is a metal-ion activated tetramer.[1]
Relevance
DXI is used commercially in the production of high fructose corn syrup.
Structural highlights
DXI active site contains 2 Mn+2 ions and the ligand binding pocket is composed of aromatic and acidic residues.[2]
3D structures of D-xylose isomerase
Updated on 11-January-2016
References
- ↑ MARSHALL RO, KOOI ER. Enzymatic conversion of D-glucose to D-fructose. Science. 1957 Apr 5;125(3249):648-9. PMID:13421660
- ↑ Collyer CA, Henrick K, Blow DM. Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. J Mol Biol. 1990 Mar 5;212(1):211-35. PMID:2319597
