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Function
PDE5 is an phosphodiesterase : this enzyme catalyzes the hydrolysis of cGMP into 5'GMP. CGMP is an usual second messager in cell transduction. PDE5 regulates its concentration by hydrolysis. If an inhibitor binds instead of cGMP, cGMP concentration increases and the stimulus continues. PDE5 inhibition is particulary used for erectile disfunction.
Human PDE5 is a PDE of class I.
Disease
Relevance
Structural highlights
PDE5 is a dimeric protein of about 270 amino acids long. C terminal has the catalytic domain and N temrinal has the regulatory domain, the GAF domain. The GAF domain "mediates the allosteric regulation of the bond with cGMP" ( à reforuler :http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518390/)
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