Nucleosome structure

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Nucleosoma

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Nucleosome is the basic structure of chromatin fiber. A nucleosome consists of a core with a histonic proteins octamer and a DNA molecule 146 bp long wound around this core in two complete turns. Histonic protein octamer includes four types of proteins: , , y . Histonic proteins are organized in dimers so:

  • Two H3-H4 dimers
  • Two H2A-H2B dimers
  • molecule wound in around octamer. Some complete the whole structure.

The more widespread secondary structure in is . 

 are arranged so positively  charged residues are in peripherycal positions , where they can stablish ionic interations with . Such electric charges distribution, gives stability to the whole structure.

References

This page is based on 1aoi file from Proteopedia.

1aoi is a 10 chain structure with sequence from Xenopus laevis. The July 2000 RCSB PDB Molecule of the Month feature on Nucleosome by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.

Proteopedia Page Contributors and Editors (what is this?)

Alejandro Porto, Eric Martz, Michal Harel

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