Sandbox Reserved 426

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Structure of Oligonucleotide/Drug complex (1xcs) 2 Introduction 3 Overall Structure 4 Binding Interactions 5 Additional Features 6 Quiz Question 1

Structure of Oligonucleotide/Drug complex (1xcs)

by Michael Beauregard, Annie Burton, Jianlong Li, Daniel Marco, and Nathaneal Park

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

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Notice the similarity in shape and side chains.

Overall Structure

spinqualitylabelsall models Three dimensional representation of the 1xcs structure. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The 1xcs (model at right) protein is a small, simple globular protein lacking any clear secondary beta sheets or alpha helices. The protein consists of two non-identical dimers. A simplified model of 1xcs is shown with the side chains removed for clarity. The protein can be followed from N to C terminus following along each strand from blue to red. Note that the strands are antiparallel where they are non-covalently bound. visualizes this bonding in the middle region of the protein, again following each strand from blue to red from N to C terminus.

Binding Interactions

spinqualitylabelsall models pdbcode, :) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Additional Features

spinqualitylabelsall models pdbcode, akjnfja Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Quiz Question 1

spinqualitylabelsall models 1xcs, chemchemchem Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image TextToBeDisplayed</scene>, which gives additional strength to the guanine–Co2+–guanine interaction. A Mg2+ B Co2+ C Ba2+ D Mg2+ See Also 1bp8 1d3x 1p3x Credits Introduction - Daniel Marco Overall Structure - Nathaneal Park Drug Binding Site - name of team member Additional Features - name of team member Quiz Question 1 - name of team member References