Sandbox Reserved 432
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| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Protein complex with cancer drug Alecensa-Alectinib (4uxl)
by Laura Feeley, Katie Kwan, Daniel Peters, Ishtiaq Rafiyu, Luke Ruksnaitis
Student Projects for UMass Chemistry 423 Spring 2016
Introduction
(Laura) Background -types of cancer it is used to treat -How it works-Inhibits ALK (Anaplastic lymphoma kinase) -insert green scene of protein bound to ligand, linking on the word Inhibits -or possible green scene on ALK kinase itself
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This is a sample scene created with SAT to by Group, and another to make of the protein.
Overall Structure
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b. Overall structure Describe the overall structure of your protein in words and make "green scenes" to illustrate your points. What elements of secondary structure are present (ie 5 alpha helices and 2 beta strands) and how are they organized? Additional description and green scenes could illustrate the polar/nonpolar distrubution of amino acids (is the inside of the barrel polar or nonpolar?), packing of amphipathic elements, etc.
Binding Interactions
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Additional Features
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Quiz Question 1
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See Also
[Structure of Human ROS1 Kinase Domain in Complex]
Credits
Introduction - name of team member
Overall Structure - name of team member
Drug Binding Site - name of team member
Additional Features - name of team member
Quiz Question 1 - name of team member
