When studying fumarase 2 sites were identified to potentially be the active site. The first site (A-site)binds inhibitors (citrate, and pyromellitic acid) and is made up of parts of 3 of the 4 subunits that comprise fumarase. The second site (B-site) binds L-malate and is made up by parts of 1 of the 4 subunits. [1].
Function
Disease
Relevance
Structural highlights
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