Function
Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1].
- GCDN S is an antibiotic cyclic polypeptide.
- GCDN D is a mixture of GCDN A, B, C.
See theoretical model of Gramicidin Channel in Lipid Bilayer.
Relevance
GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2].
Structural highlights
Gramicidin A
Protein:
, chain A in green, chain B in salmon.
Non-standard residues:
Ligands:
, C atom of methanol in cyan.
, C atom of thiocyanate in magenta.
(in purple).
