metabotropic Glutamate Receptor 5 Homo sapiens
Introduction
Biological Background
G-Coupled Protein Receptors (GPCRs) are divided into four major classes; Class A,B,C, and F.[1]. Metabotropic Glutamate Receptor 5 (mGlu5) is a class C GPCR that is involved in the Gq pathway [2]. mGlu55is highly expressed in neuronal and glial cells.
Importance
Amidase
GPCR
Structure
Overall Stucture
Key Interactions
Disease
Clinical Relevance
Hydrophobic Pocket Surrounding Mavoglurant
Further Hydrogen Bonding between protein and Mavoglurant
