Interferon receptor

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spinqualitylabelsall models Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry 3s9d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Interferon receptor (IFNR) is a cell surface receptor which binds interferon. Interferon α/β receptor binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2[1]. For more details see IFNAR and Multiple sclerosis. Interferon γ receptor binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2[2]. Interferon δ receptor binds interferon-δ[3]. Relevance Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice[4].

3D structures of interferon receptor

Updated on 30-March-2016

References

1. ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
2. ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
3. ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
4. ↑ . PMID:16451483