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Contents 1 Introduction 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

Introduction

Monoamine oxidase A (MAO-A) is an flavoenzyme, encoded in the MAOA gene on the X chromosome, present throughout the brain, central nervous system, and stomach and expressed on the outer surface of the mitochondrial membrane. Two isoforms of this enzyme are expressed in the same region, MAO-A and MAO-B, and both are responsible for the oxidative deamination of various neurotransmitters and dietary amines. More specifically, MAO-A oxidizes serotonin, epinephrine, and norepinephrine; while MAO-B oxidizes phenylethylamine and benzylamine. Both isoforms oxidize dopamine, tyramine, and N,N-dimethyltryptamine.

spinqualitylabelsall models Crystal Structure of Human Monoamine Oxidase A with Harmine Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The , illustrated in the protein image to the right, in conjunction with the color key, below, indicates the directionality of the polypeptide chain.

Amino Terminus

Carboxy Terminus

Function

Disease

Relevance

Structural highlights

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References