Mannosidase

From Proteopedia

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spinqualitylabelsall models Rice β-mannosidase complex with β-mannose, glycerol and hepes (PDB entry 2pm4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Structural highlights Function Mannosidase (MAN) is an enzyme which hydrolyzes mannose. There are 2 kinds of MAN. α-MAN which hydrolyzes α-mannose[1] and β-MAN. See some details in Molecular Playground/ERMan1. Structural highlights The active site of β-MAN contains β-mannose[2].

3D structures of mannosidase

Updated on 18-April-2016

References

1. ↑ Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, Hough E. The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation. J Mol Biol. 2003 Mar 28;327(3):631-44. PMID:12634058
2. ↑ Tankrathok A, Iglesias-Fernandez J, Luang S, Robinson RC, Kimura A, Rovira C, Hrmova M, Ketudat Cairns JR. Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 beta-D-mannosidase. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2124-35. doi:, 10.1107/S0907444913020568. Epub 2013 Sep 20. PMID:24100330 doi:http://dx.doi.org/10.1107/S0907444913020568