Methylcitrate synthase

From Proteopedia

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spinqualitylabelsall models Methylcitrate synthase dimer (PDB entry 3tag) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Methylcitrate synthase (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA[1]. See also Citrate Synthase.

3D structures of methylcitrate synthase

3hwk – MCS – Mycobacterium tuberculosis
3o8j – MCS – Salmonella enterica
3tqg – MCS – Coxiella burnetii

References

1. ↑ Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. J Bacteriol. 1999 Sep;181(18):5615-23. PMID:10482501