Mitogen-activated protein kinase kinase kinase

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Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, 2clq

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Contents

Function

Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K[1].

Disease

MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer.

3D Structures of Mitogen-activated protein kinase kinase

Updated on 28-April-2016

References

  1. ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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