5fx8

Structural highlights

Function

[MNLOX_GAEGA] Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 11S- and 13R-hydroperoxy fatty acids. At the end of lipoxygenation, the intermediate product 11S-HPODE from linoleic acid is then transformed into 13R-HPODE as the final product. It also acts on alpha-linolenic acid producing 11S-HPOTrE and 13R-HPOTrE with subsequent transformation of 11S-HPOTrE to 13R-HPOTrE as final product.^[1]

References

1. ↑ Cristea M, Engstrom K, Su C, Hornsten L, Oliw EH. Expression of manganese lipoxygenase in Pichia pastoris and site-directed mutagenesis of putative metal ligands. Arch Biochem Biophys. 2005 Feb 1;434(1):201-11. PMID:15629124 doi:http://dx.doi.org/10.1016/j.abb.2004.10.026