Structural highlights
5hwe is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 5hxu, 5hxz, 5hy0, 5hy1, 5hy2, 5hy4 |
| Activity: | Barbiturase, with EC number 3.5.2.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[BAR_RHOER] Cleaves the barbituric acid ring to yield ureidomalonic acid.[1] [2]
References
- ↑ Soong CL, Ogawa J, Shimizu S. Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase. Biochem Biophys Res Commun. 2001 Aug 10;286(1):222-6. PMID:11485332 doi:http://dx.doi.org/10.1006/bbrc.2001.5356
- ↑ Soong CL, Ogawa J, Sakuradani E, Shimizu S. Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism. J Biol Chem. 2002 Mar 1;277(9):7051-8. Epub 2001 Dec 17. PMID:11748240 doi:http://dx.doi.org/10.1074/jbc.M110784200
