5d01

Structural highlights

Function

[BSHA_BACSU] Involved in bacillithiol (BSH) biosynthesis. Catalyzes the first step of the pathway, the formation of N-acetylglucosaminylmalate (GlcNAc-Mal) from UDP-N-acetylglucosamine (UDP-GlcNAc) and L-malate.^{[1] [2]}

References

1. ↑ Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. doi:, 10.1073/pnas.1000928107. Epub 2010 Mar 22. PMID:20308541 doi:http://dx.doi.org/10.1073/pnas.1000928107
2. ↑ Upton H, Newton GL, Gushiken M, Lo K, Holden D, Fahey RC, Rawat M. Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett. 2012 Apr 5;586(7):1004-8. doi: 10.1016/j.febslet.2012.02.028. Epub, 2012 Mar 6. PMID:22569254 doi:http://dx.doi.org/10.1016/j.febslet.2012.02.028