5jj2

Structural highlights

Function

[AKA7G_HUMAN] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.^{[1] [2]}

References

1. ↑ Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL. Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol. 1999 Dec 27;147(7):1481-92. PMID:10613906
2. ↑ Bengrine A, Li J, Awayda MS. The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel. FASEB J. 2007 Apr;21(4):1189-201. Epub 2007 Jan 23. PMID:17244820 doi:http://dx.doi.org/10.1096/fj.06-6046com