1irk

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Template:STRUCTURE 1irk

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR


Overview

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

About this Structure

1IRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tyrosine kinase domain of the human insulin receptor., Hubbard SR, Wei L, Ellis L, Hendrickson WA, Nature. 1994 Dec 22-29;372(6508):746-54. PMID:7997262 Page seeded by OCA on Fri May 2 20:19:44 2008

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