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Sandbox 130

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Revision as of 18:22, 18 July 2016 by Allison Granberry (Talk | contribs)
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--Allison Granberry 21:22, 18 July 2016 (IDT)==New Delhi Metallo-Beta-Lactamase==

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Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role.

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