Structural highlights
4gr9 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 4gqi |
| Gene: | NQO2, NMOR2 (HUMAN) |
| Activity: | Ribosyldihydronicotinamide dehydrogenase (quinone), with EC number 1.10.99.2 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.[1]
Publication Abstract from PubMed
New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.
Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation.,Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008 Jul 1;413(1):81-91. PMID:18254726 doi:10.1042/BJ20071373
- ↑ Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS. Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339 doi:10.1016/j.bmcl.2012.10.005
