| Structural highlights
2xdc is a 6 chain structure with sequence from Brevibacillus brevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , |
| NonStd Res: | , , , |
| Related: | 1tk2, 1av2, 1bdw, 1c4d, 1gmk, 1grm, 1jno, 1kqe, 1mag, 1mic, 1ng8, 1nrm, 1nru, 1nt5, 1jo3, 1jo4, 1nt6, 1tkq, 1w5u, 2izq, 3l8l, 1al4, 1alx, 1alz |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Structure determination of membrane proteins by crystallographic means has been facilitated by crystallization in lipidic mesophases. It has been suggested, however, that this so-called in meso method, as originally implemented, would not apply to small protein targets having </=4 transmembrane crossings. In our study, the hypothesis that the inherent flexibility of the mesophase would enable crystallogenesis of small proteins was tested using a transmembrane pentadecapeptide, linear gramicidin, which produced structure-grade crystals. This result suggests that the in meso method should be considered as a viable means for high-resolution structure determination of integral membrane peptides, many of which are predicted to be coded for in the human genome.
Crystallizing transmembrane peptides in lipidic mesophases.,Hofer N, Aragao D, Caffrey M Biophys J. 2010 Aug 4;99(3):L23-5. PMID:20682243[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Hofer N, Aragao D, Caffrey M. Crystallizing transmembrane peptides in lipidic mesophases. Biophys J. 2010 Aug 4;99(3):L23-5. PMID:20682243 doi:10.1016/j.bpj.2010.05.011
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