Ribosomal protein S6 kinase

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Contents 1 Function 2 Relevance 3 3D Structures of Ribosomal protein S6 kinase 4 References

Function

Ribosomal protein S6 kinase (RPS6K) regulates RPS6^[1]. RPS6K activity controls the ribosome biogenesis transcriptional program.

Relevance

hRPS6K α is over expressed in breast cancer and is associated with poor prognosis^[2].

3D Structures of Ribosomal protein S6 kinase

Updated on 11-August-2016

References

1. ↑ Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012 Jan 1;441(1):1-21. doi: 10.1042/BJ20110892. PMID:22168436 doi:http://dx.doi.org/10.1042/BJ20110892
2. ↑ Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors. 2009 Feb;27(1):12-21. doi: 10.1080/08977190802556986. PMID:19085255 doi:http://dx.doi.org/10.1080/08977190802556986