Function
Ribosomal protein P2 (RPLP2) is one of the 3 phosphoproteins in the large 60S subunit of the eukaryotic ribosome. RPLP2 plays an important role in the elongation step of protein synthesis[1]. RPLP2 makes a heterodimer with dimers of RPLP1.
Relevance
Antisense RPLP2 technology has potential to slow growth of cancer cells[2].
3D Structures of ribosomal protein P2
Updated on 22-October-2017
2jdl - hRPLP2 peptide + ribosome inactivating protein trichosanthin – human
2lbf – hRPLP2 + RPLP1 dimerization domain – NMR
2w1o – hRPLP2 dimerization domain – NMR
4beh – hRPLP2 + RPLP1 – NMR
References
- ↑ Furukawa T, Uchiumi T, Tokunaga R, Taketani S. Ribosomal protein P2, a novel iron-binding protein. Arch Biochem Biophys. 1992 Oct;298(1):182-6. PMID:1524426
- ↑ Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies. Anticancer Res. 2003 Nov-Dec;23(6C):4549-60. PMID:14981896
