Single-stranded DNA-binding protein

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Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities[1].

  • Viral SSB proteins are monomeric.
  • Eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD).
  • Mitochondrial human SSB (HsmtSSB) is a homotetramer.

See also Single stranded binding protein.

3D Structures of single-stranded DNA-binding protein

Updated on 30-August-2016

References

  1. ↑ Marceau AH. Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair. Methods Mol Biol. 2012;922:1-21. doi: 10.1007/978-1-62703-032-8_1. PMID:22976174 doi:http://dx.doi.org/10.1007/978-1-62703-032-8_1

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Michal Harel, Alexander Berchansky

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