1p53

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Template:STRUCTURE 1p53

The Crystal Structure of ICAM-1 D3-D5 fragment

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling.

Disease

Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]

About this Structure

1P53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:15099525 Page seeded by OCA on Sat May 3 04:41:50 2008