Structural highlights
Publication Abstract from PubMed
The crystal structure of the tetradecanucleotide d(CCCCGGTACCGGGG)2 has previously been reported as an A-type double helix at a resolution of 2.5 A in space group P41. Here, the structure of this sequence was determined at a significantly higher resolution of 1.65 A in space group P4(1)2(1)2. The differences in crystal packing between the former and latter are described. The crystallographic asymmetric unit consists of one tetradecanucleotide duplex that spans more than one full turn of the A-helix. This structure allowed the unambiguous identification of solvent interactions.
Structure of d(CCCCGGTACCGGGG)2 at 1.65 A resolution.,Purushothaman M, Varghese A, Mandal PK, Gautham N Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):860-5. doi:, 10.1107/S2053230X1401084X. Epub 2014 Jun 18. PMID:25005078[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Purushothaman M, Varghese A, Mandal PK, Gautham N. Structure of d(CCCCGGTACCGGGG)2 at 1.65 A resolution. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):860-5. doi:, 10.1107/S2053230X1401084X. Epub 2014 Jun 18. PMID:25005078 doi:http://dx.doi.org/10.1107/S2053230X1401084X
