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Publication Abstract from PubMed

Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 A, alpha = 103.71, beta = 111.06, gamma = 105.83 degrees . The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 A with an R(cryst) and R(free) of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an alpha-helical dimerization domain.

Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis.,Gao YR, Feng N, Chen T, Li de F, Bi LJ Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):741-5. doi:, 10.1107/S2053230X15007281. Epub 2015 May 22. PMID:26057805^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.