1tqx
From Proteopedia
Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum
Overview
The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 A resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM-barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action of this enzyme. This structure is solved in the framework of the Structural Genomics of Pathogenic Protozoa (SGPP) consortium.
About this Structure
1TQX is a Single protein structure of sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum., Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG, Proteins. 2006 Feb 1;62(2):338-42. PMID:16304640 Page seeded by OCA on Sat May 3 10:16:11 2008
Categories: Plasmodium falciparum 3d7 | Single protein | Bosch, J. | Caruthers, J. | Hol, W G.J. | SGPP, Structural Genomics of Pathogenic Protozoa Consortium. | Protein structure initiative | Psi | Ribulose phosphate epimerase | Sgpp | Structural genomic | Structural genomics of pathogenic protozoa consortium | Tim barrel
