Hemolysin

From Proteopedia

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spinqualitylabelsall models α-hemolysin heptamer (PDB code 7ahl). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Hemolysin (HL) is exotoxin from bacteria which causes lysis of red blood cells[1]. Hemolysin from the bacterium Clostridium are called alpha-toxin (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. See details for α-hemolysin in Pore forming toxin, α-hemolysin. See details of hemolysin E in Molecular Playground/ClyA. For toxins in Proteopdia see Toxins. Relevance HL acts as a virulence factor in the pathogenesis of invasive infections[2].

Contents 1 3D Structures of hemolysin 2 3D Printed Physical Model of Hemolysin 2.1 The MSOE Center for BioMolecular Modeling 3 References

3D Structures of hemolysin

3D Printed Physical Model of Hemolysin

Shown below is a 3D printed physical model of Hemolysin. The model is shown in alpha carbon backbone format with each chain colored uniquely.

Image:Hemolysin1 centerForBiomolecularModeling.jpg

The MSOE Center for BioMolecular Modeling

The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery.

Updated on 20-April-2018

A full page in Proteopedia exploring 7ahl is found here.

References

1. ↑ Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774
2. ↑ Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec;10(12):575-80. PMID:12564994