5w9s

Structural highlights

Function

[CXXC5_HUMAN] May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).^{[1] [2] [3]}

References

1. ↑ Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009, Jan 30. PMID:19182210 doi:http://dx.doi.org/10.1182/blood-2008-07-170035
2. ↑ ZHANG M, WANG R, WANG Y, DIAO F, LU F, GAO D, CHEN D, ZHAI Z, SHU H. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. Sci China C Life Sci. 2009 Jun;52(6):528-38. doi: 10.1007/s11427-009-0083-7. Epub, 2009 Jun 26. PMID:19557330 doi:http://dx.doi.org/10.1007/s11427-009-0083-7
3. ↑ Aras S, Pak O, Sommer N, Finley R Jr, Huttemann M, Weissmann N, Grossman LI. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res. 2013 Feb 1;41(4):2255-66. doi: 10.1093/nar/gks1454. Epub 2013 , Jan 8. PMID:23303788 doi:http://dx.doi.org/10.1093/nar/gks1454