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Signalosome

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Revision as of 08:53, 6 February 2020 by Michal Harel (Talk | contribs)
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Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code 4d10)

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3D Structures of COP9 signalosome

Updated on 06-February-2020

4lct – hCOP9 subunit 1 – human
4d0p – hCOP9 subunit 4
1ufm – hCOP9 subunit 4 PCI domain - NMR
4f7o – hCOP9 subunit 5
5jog, 5joh, 5m5q – hCOP9 subunit 5 + inhibitor
4qft – hCOP9 subunit 6
4e0q, 4r14 – hCOP9 subunit 6 MPN domain
4d10, 4d18, 4wsn – hCOP9 subunits 1,2,3,4,5,6,7A,8
6r7n, 6r7i, 6r7h – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM
6r7h – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM
6r6h – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM
3chm – hCOP9 subunit 7 – Arabidopsis thaliana

References

  1. ↑ Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x

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Michal Harel

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