C-X-C motif chemokine (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.[1]
• CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.
